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Neandertal DNA

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Lactase and the Neandertals

New research shows that a common gene variant that may explain some lactase persistence in East Asia is introgressed from Neandertals.

A concrete sculpture showing a Neandertal woman with child at breast
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A hard ceiling on modern human dispersal

Neandertal DNA in some of the oldest modern human genomes establishes a short timeline of 50,000 years for the out-of-Africa founder event.

Silhouette cutout of Neandertal with trees and landscape visible through the cutout
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Top 10 discoveries about ancient people from DNA in 2024

New resolution is emerging of some events in ancient human populations, and a clearer view of some parts of the genome.

Art illustration of DNA strands
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A look at the Neanderthal from Altamura

The exceptional skeleton encased in calcite has started to yield insights about early Neanderthals.

A skull and other bones encased with coralloid calcite encrustation
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Late Neandertals: more diverse than most scientists thought

The new “Thorin” genome from Grotte Mandrin represents a previously-unknown Neanderthal deep history.

Fragments of a jaw with teeth visible in an archaeological site
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Vagrant birds and ancient human habitats

People killed the Carolina parakeet. An inquiry into their historic population range helps illustrate the challenges of understanding ancient human populations.

A painting showing several green parakeets in varied poses
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Tracing the signature of African-to-Neandertal gene flow

A new study of African genetic variation yields a more accurate picture of the genetic exchanges between ancient Africans and Neandertals 250,000 years ago.

DNA with chains of bubbles rising from it in a fluid
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Interaction and mixture: big picture and small

From the level of function of a single gene up to the movements of entire populations, our evolution was built from mixture.

Painting from 1883 of stone age dancers feasting around a fire
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When did human chromosome 2 fuse?

More and more, it looks like this event happened shortly before a million years ago, in the common ancestors of Neandertal, Denisovan, and African ancestral humans.

When did human chromosome 2 fuse?
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What color were Neandertals?

Even with whole genomes, scientists can't say very precisely what pattern of skin, hair, and eye pigmentation was in ancient populations like the Neandertals.

Fifteen Neandertal faces of varied ages and complexions
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Explaining the X chromosome hole in Neandertal ancestry

Natural selection reduced the variation on human X chromosomes in populations with the most Neandertal and Denisovan mixture. It may have been meiotic drive.

A fluorescence image of chromosomes in cells undergoing meiosis
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Many people have a little Neandertal in the brain. Does it matter?

Research has started to show the ways that introgressed genes from Neandertals affect brain shape in living people.

Anatomical model of a brain
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Solving the mystery of the Red Deer Cave people

New DNA evidence is revealing the genetic relationships of ancient groups from southern China, showing how they were connected to living people across the region.

Two reconstructed partial skulls side by side representing the Red Deer Cave people
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Top 10 discoveries about ancient people from DNA in 2022

Research on ancient genomes has moved way beyond population mixture into broader questions about how ancient people lived and interacted with their environments.

A researcher wearing protective mask, hair net, and gloves is reaching toward an archaeological profile with a test tube.
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The Nesher Ramla site: a third way between Neandertals and modern humans?

Fragments representing people who lived just before Skhūl and Qafzeh seem outside the expectations for these “early modern humans” or for Neandertals.

Archaeologists working on a large, terraced excavation area under a white canopy.
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Zlatý kůň and the Neandertal heritage of first Europeans

A skull from Czechia represents an individual from one of the earliest European modern human populations to encounter Neandertals.

Zlatý kůň cranium with information
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Research highlight: Accurate depiction of uncertainty in ancient DNA research: The case of Neandertal ancestry in Africa

An article in the Journal of Social Archaeology looking at how researchers shaped public perceptions of Neandertal DNA heritage in living people.

Cover page of "Accurate depiction of uncertainty in ancient DNA research"
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Neandertals got 6% of their genomes from Africa

An analysis by Melissa Hubisz and coworkers finds that mtDNA is not all that Neandertals received from our African ancestors

A Banksy-style portrait of a Neandertal wearing a blazer
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How much Neandertal DNA do today's African peoples have?

New research shows that today's populations in Africa have around one third the Neandertal ancestry as people in Eurasia.

Neandertal face with hand holding a spear
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Lecture: Who were the ancestors of the Neandertals?

Looking at what we know about Neandertal origins and how our understanding has changed in the last decade.

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Should we be surprised if Neandertals, Denisovans, and modern humans didn’t form stable hybrid zones?

A geneticist asks why we don't see more persisting hybrid populations, and I find an answer in the theory of population source-sink dynamics.

A Neandertal artist's reconstruction at the Neanderthal Museum, wearing a suit and holding a stone tool.
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How much sex did it take for Neandertal DNA to enter modern populations?

Addressing a widespread misconception about what geneticists are really measuring when they look at population mixture.

A painting of the biblical figures Jacob and Esau
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Another Denisovan from Denisova Cave

A review of the 2015 work identifying the Denisova 8 specimen by Susanna Sawyer and coworkers.

Denisova 8 molar
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What is the ‘braided stream’ analogy for human evolution?

A discussion of the way that reticulation has manifested across human evolution, with reference to an essay by Clive Finlayson.

Channels of water draining in sand showing a braided stream network
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The FoxP2 protein sequence from Neandertals and Denisovans is shared by many people today

A study of sequence variation shows a possible selected change among living people, but many still have a form shared with Neandertals and Denisovans.

A protein structure model
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My reactions on the publication of the first draft Neandertal genome

Publication of the first draft of a Neandertal genome reveals that these ancient humans are among the ancestors of people living today.

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A mysterious mitochondrial sequence from Denisova Cave, Russia

A small fragment of finger bone with a DNA sequence that represents a previously-unknown form of hominin.

A fragment of finger bone upon a chalk outline of a hand skeleton