john hawks weblog

paleoanthropology, genetics and evolution

"Brittle techniques"

Mon, 2013-01-28 00:03 -- John Hawks

I was pointed to a rant from early last year written by Fred Ross: "A farewell to bioinformatics".

Like any good rant, it is extreme and I don't endorse it, but like all good rants it has kernels of truth.

This all seems an inauspicious beginning for a field. Anything so worthless should quickly shrivel up and die, right? Well, intentionally or not, bioinformatics found a way to survive: obfuscation. By making the tools unusable, by inventing file format after file format, by seeking out the most brittle techniques and the slowest languages, by not publishing their algorithms and making their results impossible to replicate, the field managed to reduce its productivity by at least 90%, probably closer to 99%. Thus the thread of failures can be stretched out from years to decades, hidden by the cloak of incompetence.

Data structures in bioinformatics should be designed for robusticity and ease of re-use by different research teams. But that won't happen unless grant money to support data collection requires it. Open access to data is wonderful, but it is only the first step toward open science.

Neandertals

For years, I've worked on their bones. Now I'm working on their genes. Read more about the science studying these ancient people.

Denisova

From a finger bone of an ancient human came the record of a completely unexpected population. My lab is working on the science of the Denisova genome.

Acceleration

The advent of agriculture caused natural selection to speed up greatly in humans. We're uncovering some of the ways that populations have rapidly changed during the last 10,000 years.

Malapa

Just outside Johannesburg, the Malapa site is producing some of the most exciting finds in human evolution. This site is the headquarters of the Malapa Soft Tissue Project.