john hawks weblog

paleoanthropology, genetics and evolution

Reviving old viruses buried in the genome

Wed, 2006-11-01 22:39 -- John Hawks

This story caught my attention:

In a controversial study, researchers have resurrected a retrovirus that infected our ancestors millions of years ago and now sits frozen in the human genome. Published online by Genome Research this week, the study may shed new light on the history of these genomic intruders, as well as their role in tumors. Although this particular virus, dubbed Phoenix, is a wimpy one, some argue that resuscitating any ancient virus is inherently risky and that the study should have undergone stricter reviews.

Basically, they took a consensus sequence of one family of human endogenous retroviruses, which have implanted their own genomes within ours over millions of years, and used the sequence to build a real virus. And it worked, creating a weakly infectious agent.

Lots of people think this is a bad idea. After all, resurrecting ancient viruses is like a box of chocolates: you never know when they'll escape from the petri dish and start eating your flesh off.

Personally, if it wasn't such a bad idea, I have to wonder why they gave the virus such an obviously military-sounding name! I mean, "Phoenix"?

Neandertals

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Denisova

From a finger bone of an ancient human came the record of a completely unexpected population. My lab is working on the science of the Denisova genome.

Acceleration

The advent of agriculture caused natural selection to speed up greatly in humans. We're uncovering some of the ways that populations have rapidly changed during the last 10,000 years.

Malapa

Just outside Johannesburg, the Malapa site is producing some of the most exciting finds in human evolution. This site is the headquarters of the Malapa Soft Tissue Project.