How next-gen sequencing changes the work of a small biology lab
David Roy Smith in the current Frontiers in Genetics has an opinion article that reflects on the way that next-generation sequencing technologies have change...
All posts tagged with sequencing
Sequencing baby Khan
MIT Technology Review has an article this week about Razib Khan’s efforts to sequence his baby son in utero: “For One Baby, Life Begins with Genome Revealed”.
Baiting ancient DNA with RNA
A new paper by Meredith Carpenter and colleagues describes a novel method that can greatly enrich the yield of DNA from ancient samples:
When sequencing genomes is too boring for journals
Sequencing bacterial genomes is now the scope of project routinely undertaken by undergraduates just learning how to do research. What was once an empirical ...
Everyday genomes
From the Guardian, a pause to consider how ordinary complete genome analysis has become: “Genome research: discovery as an everyday event”.
A new high-coverage Neandertal genome
Today, Svante Pääbo’s group at the Max Planck Institute for Evolutionary Anthropology released high-coverage sequence data from a toe bone from Denisova Cave...
Privacy of genetic research participants
Misha Angrist, writing in Nature News comments (“Genetic privacy needs a more nuanced approach”) on the recent study that demonstrated the possibility of fin...
Finding sequencing methods in the library
Jay Shendure and Erez Lieberman Aiden have a recent review in Nature Biotechnology that provides some recent data on the falling cost and increased use of ge...
Do we need an offshore data haven for genomes?
Razib Khan comments on 23andMe’s pursuit of FDA clearance for their genome service:
Human population history makes a difference
Alon Keinan and Andrew Clark have a short report in the current Science examining the effects of recent human population growth on the expected spectrum of h...
Finding the scary genes
John Lauerman reports in BusinessWeek on his experience participating in the Personal Genome Project:
Genotyping the intro class
Holly Dunsworth, at the University of Rhode Island, is undertaking a unique project with her undergraduate course this semester, providing 23andMe genotyping...
The Mayflower criminal registry
Of some interest with respect to DNA databases and privacy concerns: “DNA links 1991 killing to Colonial-era family”.
Sequencing is outpacing computing
The New York Times notices DNA sequencing’s Malthusian trap: “DNA sequencing caught in deluge of data.”
Sequence the old, fast
The Archon Genomics X Prize is a $10 million contest to see what company or organization can develop a low-cost accurate sequencing technology. The AP’s Malc...
Exome sequencing as a stopgap
The new Genome Biology has a perspective piece by Jacob Tennessen and colleagues, titled “The promise and limitations of population exomics for human evoluti...
Personalized genomics beats personalized genetics
Joe Pickrell encountered sticker shock when faced with the prospect of a medical sequencing test: “The week that I worried I had a rare genetic disease”.
Delete the troubling data
Misha Angrist turns on the sarcasm filter for a proposal to discard raw data that may trouble research subjects (“If you want to destroy my sweater”):
Genomes too cheap to meter
Matthew Herper is a science and medicine contributing writer at Forbes.com. He has just written a series of posts themed as “Gene Week”, focusing on advances...
Now for anthropological genomics
The first of the papers describing results from the 1000 Genomes project has been released today in Nature 1000Genomes:Nature:2010.
A low human mutation rate may throw everything out of whack
Last week, a paper looking for the genetic causes of Miller syndrome reported the whole genomes of four members of a single family: two siblings with the dis...
Deep versus wide genomes
Remember Genome 10K? Well, here’s a new study by Michel Milinkovitch and colleagues, that points out the deficiencies of comparative data from 1X genomes:
Sequencing news
Daniel MacArthur reports from the Advances in Genome Biology and Technology meetings are full of little snippets of next-generation sequencing news; good if ...
Complete genomes
John Timmer gives a great summary of the new paper in Science covering the Complete Genomics sequencing method.
DNA tech
IBM joins the next-gen sequencing race:
Data warehousing in genomics interview
Software publisher O’Reilly is running an interview with David Dooling, data chief of the Genome Sequencing Center at Washington University: “Sequencing a ge...
Your whole genome for $5000
In yesterday’s NY Times: