Neandertal ancestors of African populations
Earlier this year, Lu Chen and coworkers from Joshua Akey’s research group published an assessment of the amount of Neandertal ancestry in the genomes of pre...
All posts tagged with 1000 Genomes Project
Human population history makes a difference
Alon Keinan and Andrew Clark have a short report in the current Science examining the effects of recent human population growth on the expected spectrum of h...
When genes break: validating loss-of-function variants
Daniel MacArthur and colleagues have an important paper in Science, titled “A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes” M...
Mailbag: Neandertal genes across the Strait of Gibraltar
Re: Neandertal gene variants in Yoruba:
Which population in the 1000 Genomes Project samples has the most Neandertal similarity?
This post is from 2012. The comparisons here were based on information that has changed over time, with it now clear that East Asian populations have a small...
Watch who you call "extinct"!
Sometimes people wonder why human genetics projects should bother to involve anthropologists.
More on the mutation rate
I’ve received several questions over the last few weeks about human genome-wide mutation rates. Some people are noticing heterogeneity in mutation rate estim...
What is the human mutation rate?
Last spring I wrote about a study that used whole-genome comparisons between parents and offspring to estimate the rate of per-genome mutation in humans (“A ...
Copy number variation in 1000 Genomes
When I wrote earlier in the week about the 1000 Genomes Project results, I mentioned that a second paper was being published in Science. That paper, by Peter...
Now for anthropological genomics
The first of the papers describing results from the 1000 Genomes project has been released today in Nature 1000Genomes:Nature:2010.
A low human mutation rate may throw everything out of whack
Last week, a paper looking for the genetic causes of Miller syndrome reported the whole genomes of four members of a single family: two siblings with the dis...
"Filled up with other books"
The 1000 Genomes Project is for people. Now, is it time for 10,000 vertebrate genomes? Erika Check Hayden reports on the idea in Nature news:
Spatial variation and near-fixed selected alleles
I couple of people have asked me about a new paper in PLoS Genetics by Graham Coop and colleagues, titled, “The role of geography in human adaptation.” The p...
Ascertainment into the future, what worth datasets?
A reader helpfully pointed me to a new paper in PNAS that looks at the sampling scheme of the 1000 Genomes Project from the point of view of SNP discovery. T...