john hawks weblog

paleoanthropology, genetics and evolution

celebrities

  • Sit down and shut up

    Tue, 2012-05-08 23:22 -- John Hawks

    Carole McGranahan describes a memorable case where academics shut down public discussion of their work: "Dialogue with the Public: Adam Yauch and Academic Snobbery". The subject of the story is the recently deceased Beastie Boys member Adam Yauch.

    Before anyone on the panel could reply, one of the conference organizers—a Harvard professor—stood up and said forcefully that this was an “academic conference” and that “emotional” questions would not be entertained. He made it clear we were here to discuss real politics in an academic, dispassionate manner. That is: in discussing politics we were to be apolitical.

    A celebrity unrecognized by the academics, asking a simple question.

  • Darwin's Y

    Fri, 2011-04-01 08:20 -- John Hawks

    The Telegraph has done a puff piece about the Genographic testing of Charles Darwin's great-great-grandson.

    Last week I got to attend an incredible panel discussion that focused on the issue of genetic testing and identity. How and why do people connect the results of a genotyping test to their deep conception of themselves?

    The Genographic results are only Y chromosome and mtDNA, a tiny fraction of an individual's ancestry. Charles Darwin only accounts for around 6 percent of this descendant's ancestry (possibly a shade more genetically, considering the inbreeding). The Y chromosome is not the seat of the soul. And yet:

    Mr Darwin, whose great-grandfather was Darwin's astronomer son George, said the test showed that the desire for knowledge and thirst for discovery was in his genetic makeup.

    "I was always a bit concerned that I hadn't inherited Charles Darwin's scientific abilities, but I hoped I had inherited his adventurous abilities, his desire to go over the hill and see what was on the other side," he said.

    Interesting how people construct a story about the connection between genes and identity, isn't it?

  • Violet eyes

    Sun, 2011-03-27 18:03 -- John Hawks

    Oh, I suppose I should go ahead and link to that Elizabeth Taylor mutation article:

    Double rows of eyelashes are usually the result of a mutation at FOXC2, a gene that influences all kinds of tissue development in embryos. FOXC2 mutations are thought to be responsible for, among other things, lymphedema-distichiasis syndrome, a hereditary disease that can cause disorders of the lymphatic system in addition to double eyelashes.

    It's interesting, in its way. But I really want to pick a bone with this:

    I was slightly crushed, then, to discover that, by most official accounts, Taylor's eyes were actually a deep blue that appeared purple when enhanced by lighting and makeup. (Truly violet eyes occur only in albinos.)

    Blue eyes are blue because of the quality of light available for diffraction. There's no blue pigment in them, just as there is no blue pigment in the sea to make it blue. (Amusement park water is a different story...). This is why we can talk sensibly about eyes that always seem to be changing in color.

    I see no reason to deny the woman her violet eyes. Heck, in my yard the violets (the sweet yard-growing kind, not the African kind) aren't even violet! Dark blue eyes with a touch of eumelanin in a shallower configuration might not match the crayon for color, but could easily be violet to anyone at Richard Burton distance.

  • Neandertal anti-defamation files, 8

    Thu, 2011-01-20 12:52 -- John Hawks

    OK, at ScienceOnline2011 I did a little bit of talking about Neandertals represented in art. So this entry in the NAD files truly pains me.

    You see, Britney Spears Watcher picked up that story from last year about how digit ratios predict that Neandertals were oversexed.

    Neanderthals may be lampooned as slack-jawed low-brows who could just about wield a heavy club on a good day, but in one important respect they outperformed us: in the number of sex partners.

    Well, yes, it is a delicious irony for a blog devoted to Britney Spears to refer to anyone as a "slack-jawed low-brow" with too many sex partners. But that's not what had me concerned. No, it was the accompanying picture:

    Neandertal Ken Bump

    Dude! They didn't even give him a Ken Bump.

    I mean, really -- I know that Britney Spears fans are always looking for quality family-friendly material, but this is just rude. Plus, I think it's sort of obviously one of those times like when they put Oprah's head on Ann-Margret's body.

    UPDATE (2011-01-20): Gretchen says it's a Neandertal merkin.

    And that, my friends, is Google gold.

  • Culturomics

    Thu, 2010-12-16 14:39 -- John Hawks

    From the Guardian: "Google creates a tool to probe 'genome' of English words for cultural trends".

    "Interest in computational approaches to the humanities and social sciences dates back to the 1950s," said Michel, a psychologist in Harvard's Program for Evolutionary Dynamics. "But attempts to introduce quantitative methods into the study of culture have been hampered by the lack of suitable data. We now have a massive dataset, available through an interface that is user-friendly and freely available to anyone."

    When I was an undergraduate doing research on Shakespeare, I pored through a concordance that had been constructed by computer in the late 1960's, which had given rise to several kinds of textual analyses (including some of the authorship disputes). There has long been an interest in that kind of quantitative analysis, and the thought that you can do it now for 5 million books is pretty daunting. The patterns of borrowing may be quite analogous to the analysis of reticulation in biological networks, I would imagine.

    The article presents some interesting factoids, focusing mainly on the appearance of celebrity names. There's this:

    "Science is a poor route to fame. Physicists and biologists eventually reached a similar level of fame as actors but it took them far longer," wrote the researchers. "Alas, even at their peak, mathematicians tend not to be appreciated by the public."

    Alas.

    I suppose somebody could do much more interesting work on spoken English by analyzing NSA recordings...

  • Ozzy Osbourne, archaic human

    Mon, 2010-10-25 16:28 -- John Hawks

    Via a reader: The Daily Mail really aims for the lowest common denominator of genetics: "We've all suspected, now it's official: Ozzy Osbourne IS a Neanderthal"

    He claims his ‘superhuman’ genes have kept him healthy despite a lifetime of rock ’n’ roll excess.

    And now it seems science may back up Ozzy Osbourne’s theory that he has a particularly hardy family tree.
    Researchers studying his DNA have found that the singer is the descendant of a Neanderthal man.

    This is almost an entry in the Neandertal anti-defamation series. What holds it back is the clear involvement of some shady genetics company. Get this:

    The researchers also examined the gene the body uses to break down alcohol and discovered an ‘unusual variant’ which could have helped Osbourne survive during the years when he drank up to four bottles of Cognac a day.

    ‘Given the swimming pools of booze I’d guzzled over the years – not to mention all the [drugs] – there’s really no plausible medical reason why I should be alive,’ he told The Sunday Times.

    What a crock! I mean it's one thing to tell people their genomes have Neandertal markers. I mean, that's a crock, too, since we have no clear marker list yet. But at least it's a harmless entertainment-only kind of a crock.

    Now, when you tell an alcoholic that he has an "unusual variant" that "could have helped" metabolize alcohol better -- that's an altogether deeper level of crockery.

    I know, it's like the "Weekly World News", but cheez Louise, what a crock!

  • Starr

    Wed, 2010-07-07 18:13 -- John Hawks

    Ringo Starr turns 70 years old today. Many are reminiscing about some music group he was apparently part of. As for myself, I will forever treasure his genius performance in the 1981 film, Caveman.

    What? That movie totally launched Dennis Quaid's career! That and Jaws 3D.

  • GET smart

    Fri, 2010-04-30 10:02 -- John Hawks

    Carl Zimmer describes his experience as a master of ceremonies (with Robert Krulwich) at the Genomes, Envrionments, Traits conference ("A day among the genomes"). The conference, organized by George Church, got together on one stage almost everyone who has publicly made known their whole genome.

    David Dobbs was in the audience and describes the show: "Genomes, cool conferences, and what the hell to tell people about behavioral genes". He also describes some of the backchannel talk that focused on the more concrete element of trying to predict things from genomes -- including behavioral variation:

    As I'm quite interested in [behavior and mood], I couldn't help but notice that they didn't come up a lot in the formal discussions. But when I talked to people on the side, including some of those who had their genomes run, they usually confirmed my impression that people take a particularly keen intereste in genes related to things like mental health or behavior -- depression, bipolar, hyperactivty, aggression. "Oh God yes," one person told me. "Unless you're really worried about cancer or something, that's the first thing people look at. 'Do I have the crazy gene?'" Yet by my read, neither the industry nor the research community quite knows what to tell people to do with that information -- even as we move closer to making it cheaply available.

  • This weeks' genomes

    Fri, 2010-03-12 19:53 -- John Hawks

    Actress Glenn Close joins the ranks of the genomed; Daniel MacArthur discusses the celebrity genomics trend.

    He covers in greater detail the James Lupski genome story, in which the geneticist sequences his own genome to find out what causes his own genetic disorder, Charcot-Marie-Tooth disease. Beside that success story, he places a second study this week that had a lot more trouble -- a case in which complete genome sequencing of four members of a family could not by itself find the causative variant for two siblings' Miller syndrome.

    The basic problem here is that we're still extremely bad at differentiating between mutations causing serious disease and perfectly benign polymorphisms - each of us have genomes littered with genetic variants that look like nasty mutations but have little or no effect on health. In fact, Lupski's genome illustrates this nicely: one of the mutations causing his disease is a premature stop codon that disrupts the function of a gene - but his genome also contains an additional 120 stop codons disrupting other genes, presumably without severe health effects.

    So all of us are walking around with hundreds of gene-disrupting variants, and finding the single causative gene amongst all that noise is seriously challenging.

    We've been talking about stop codons and pseudogenes a lot here in the Hawks lab this week.

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Neandertals

For years, I've worked on their bones. Now I'm working on their genes. Read more about the science studying these ancient people.

Denisova

From a finger bone of an ancient human came the record of a completely unexpected population. My lab is working on the science of the Denisova genome.

Acceleration

The advent of agriculture caused natural selection to speed up greatly in humans. We're uncovering some of the ways that populations have rapidly changed during the last 10,000 years.

Malapa

Just outside Johannesburg, the Malapa site is producing some of the most exciting finds in human evolution. This site is the headquarters of the Malapa Soft Tissue Project.