john hawks weblog

paleoanthropology, genetics and evolution

race

  • Plain statements on race, from Earnest Hooton (1936)

    Thu, 2008-12-04 11:38 -- John Hawks

    This seems to be "Race Month" on the internet. I thought some history might be enlightening, since most people seem to be just writing off the tops of their heads.

    Earnest Hooton was the pre-eminent physical anthropologist in the United States in the first half of the twentieth century. This status was partly attributable to his voluminous work and popular writing, and partly because he directly trained most of the important figures in the next generation of physical anthropologists. Most of us today can still trace our academic lineage to Hooton.

    Much of Hooton's work directly attempted to quantify racial characteristics and their distribution in the world. Hooton used an essentialist concept of race -- races were "ideal types" expressed variably in living people -- but emphasized that today's humans are inevitably products of the mixture of different ancient populations. In his view, "pure races" do not presently exist, and different populations today reflect different blends of ancestral races.

    I wanted to quote extensively from his 1936 essay in Science, titled "Plain Statements on Race," because it serves as a good illustration of the way one prominent scientist who studied human races reacted to the social uses of the race concept in the 1930's.

    From immemorial antiquity hereditary variations of bodily form have been made the basis of charges of racial inferiority in mentality and in capacity for civilization. With this contemptible subterfuge our European ancestors justified their enslavement of the Negro and their virtual extermination of the Indian and of many other primitive peoples. The "White man's burden" has been mainly one of hypocrisy. With no more savage worlds left to conquer (save only Ethiopia), the White man has turned this same vicious argument to use against his own kind, committing more crimes in the name of race than have ever been perpetrated in the name of liberty.

    Under these circumstances, a physical anthropologist, who has devoted most of his research activity to the study of race for nearly a quarter of a century, desires emphatically to dissociate the finding of his science from the acts of human injustice which masquerade as "racial measures" or "racial movements" or even "racial hygiene."

    I do not claim to speak for all physical anthropologists, many of whom are either too wise or too timid to speak at all upon this subject, preferring to pursue their researches in academic seclusion, rather than cry their wares in the marketplace and run the risk of being pelted by the rabble. For myself, I prefer to be the target of rotten eggs, rather than to be suspected as a purveyor of that odoriferous commodity.

    In his essay, Hooton argues that the description of human variation should not predicate proscription within society.

    Within each and every race there is great individual variation in physical features and in mental capacity, but no close correlation between physique and mentality has been scientifically demonstrated. Knowledge of human heredity is still far from perfect ...

    ...Each racial type runs the gamut from idiots and criminals to geniuses and statesmen. No type produces a majority of individuals from either end of the scale. While there may be specific racial abilities and disabilities, these have not yet been demonstrated. There are no racial monopolies either of human virtues or of vices.

    The modern biologist will find many conceptual errors within Hooton's "plain words," in particular his focus on ancestral races as products of a long process of isolation. But Hooton's description of the social aspects and consequences of the race concept mostly overlap with those promoted by Ashley Montagu and others, which became dominant within postwar anthropology.

    This is significant in Hooton's words with respect to race, because with respect to human biological variation generally, he remained a committed eugenicist. Here's the end of the essay:

    I believe that this nation requires a biological purge if it is to check the growing numbers of the physically inferior, the mentally ineffective and the anti-social. These elements which make for social disintegration are drawn from no one race or ethnic stock. Let each of us, Nordic or Negro, Aryan or Semite, Daughter of the Revolution or Son of St. Patrick, pluck the beam from his own eye, before he attempts to remove the mote from that of his brother. Every tree that bears bad fruit should be cut down and cast into the fire. Whether that tree is an indigenous growth or a transplantation from an alien soil, matters not one whit, so long as it is rotten.

    This is not exactly the soft touch approach.

    Hooton concluded that race, as a practical matter, was not a fit criterion for sorting humans into groups with different intrinsic moral values. In practical terms, attempting to alter human nature by race eugenics was bound to be ineffectual. In moral terms, Hooton's prose -- in the early text referring back to Biblical example -- shows his opinion that race was a "specious excuse" for immoral deeds.

    This moral opinion was quite distinct from his view of human variation, in which he showed by his constant practice a belief that humans could be sorted into races on the basis of combinations of features, and that these groups were at a different level from "ethnicities," "nationalities," and other possible groupings. In his view, race and culture were potentially distinct -- in that people of different races may adopt the same culture, and that racial characteristics have a different mode of transmission.

    That's one perspective from history. I'll be adding some others this week.

    References:

    Hooton EA. 1936. Plain statements about race. Science 83:511-513. doi:10.1126/science.83.2161.511

  • Population genomics rising

    Thu, 2008-11-06 08:30 -- John Hawks

    Genetic Future has been on fire lately, with various announcements from and about genomics testing companies. More on that later. Today, he reflects upon the publication of two non-European genomes in the current Nature:

    So attention has already well and truly turned to converting sequence into biological meaning - and that's a job that will ultimately require many hundreds of thousands of genome sequences, each attached to information about biological traits and disease status. That means the end of the brief era of high-profile "single human genome" papers, which started in a sense with the anonymised, pooled and fragmented human reference sequences published in 2001, peaked with the celebrity genomes of Venter and Watson in 2007/2008, and now ends (I suspect) with two anonymous non-European genomes.

    Human genetics now moves into a phase of new challenges and rewards - the era of population genomics.

    It's a good post, with the thesis that we will never again see a paper published in a major journal to report the genome sequence of a single individual. I demur for a special case: We'll see fossil and archaeological genome sequences in major journals for quite some time to come. I suppose after a few Egyptian or Neolithic genomes, those also will be reported many individuals at a time. But Pleistocene remains will always be singular.

    In the meantime, of course population genomics is what we're all about here in the Hawks lab. Single-locus genetics has gone the way of the dodo. Er...I suppose if you study dodos, you'd better go whole-genome with them, too. My only question: exactly how much hard drive space am I expected to have, if I'm going to deal with 100,000 genomes?

  • The Lemba story jumps the shark

    Tue, 2008-02-26 20:07 -- John Hawks

    Not only are they one of the lost tribes of Israel, now Tudor Parfitt says they are hiding the Lost Ark of the Covenant:

    Parfitt started wondering about another aspect of the Lemba's now-credible oral history: a drumlike object called the ngoma lungundu. The ngoma, according to the Lemba, was near-divine, used to store ritual objects, and borne on poles inserted into rings. It was too holy to touch the ground or to be touched by non-priests, and it emitted a "Fire of God" that killed enemies and, occasionally, Lemba. A Lemba elder told Parfitt, "[It] came from the temple in Jerusalem. We carried it down here through Africa."

    Needless to say (since Parfitt's book is the companion for a History Channel special on March 2), he finds the ngoma, and it has an "uncharacteristic burnt-black bottom hole." Naturally, he is forced into the only possible conclusion: The Ark of the Covenant was actually a gunpowder-powered spirit drum bazooka:

    Parfitt thinks that whatever the supernatural character of Ark, it was, like the ngoma, a combination of reliquary, drum and primitive weapon, fueled with a somewhat unpredictable proto-gunpowder. That would explain the unintentional conflagrations.

    Oh, yes. Or...maybe the problem is that they tried to keep some of those red-hot spirit stones from the Temple of Doom in it. Anyway, let's not be deterred by petty technicalities like carbon dating:

    So, had he found the Ark? Yes and no, he concluded. A splinter has carbon-dated the drum to 1350 AD -- ancient for an African wood artifact, but 2,500 years after Moses. Undaunted, Parfitt asserts that "this is the Ark referred to in Lemba tradition" -- Lemba legend has it that the original ngoma destroyed itself some 400 years ago and had to be rebuilt on its own "ruins" -- "constructed by priests to replace the previous Ark. There can be little doubt that what I found is the last thing on earth in direct descent from the Ark of Moses."

    If you don't know the Lemba genetic story, I like this Slate article by Jon Cohen. They are a South African tribe. The basic idea is that Lemba men carry a relatively high proportion of Middle Eastern Y chromosome haplotypes, including the famous Cohen modal haplotype, otherwise common in men of Jewish descent. Parfitt spent time with the Lemba and helped popularize their folkloric story of an ancient exodus from the north.

    The article introduces Parfitt as a "real life scholar-adventurer," which as you can imagine inspired this conversation:

    Me: Should I make the transition to "scholar-adventurer"?

    Gretchen: You can be a scholar-adventurer as long as it doesn't involve the Lost Ark, or King Solomon's mines, or the Holy Grail.

    Me: So pretty much your classic Indiana Jones adventures are out?

    Gretchen: Yeah. Also, any kind of ape encounter, especially involving sign language. Don't go in search of Zinj -- that had a bad end. Stay away from any kind of oceanic exploration, where they have a big "facility" under the sea -- always a bad end; everybody dies.

    But if you're looking for the Lost World, or -- ooh -- the Skunk Ape. Or Chupacabra.

    Me: No, the cryptozoologists don't like me. How about the Maltese Falcon?

    Gretchen: Ooh, yeah -- something with that hint of mystery and danger. You may also search for "Rosebud."

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  • Wherein the New York Times says Hawks was right

    Sat, 2007-11-24 22:58 -- John Hawks

    Nearly two years ago now I wrote a column for Slate arguing that DNA genealogy tests were misleading people. Here's what I wrote:

    From a practical point of view, that is the biggest problem with today's genetic genealogy tests. In many cases, they can't tell you what you don't already know. And unlike DNA fingerprinting tests with error rates of one in a billion or less, the chance of misidentifying ancestral groups in these genealogy tests may be 5 percent or higher. With this chance of error, the test won't be wrong about a full Native-American grandparent, but it might be wrong about a great-great grandparent. In addition, SNPs that separate central Africans from northern Europeans aren't nearly as good at separating Ethiopians from Arabs. So, in the test results of some African-Americans, European means Europe, while in others, it may mean East African, or Arab, or Indian. Depending on where his African ancestors came from, Gates' apparently European origins might lie somewhere else entirely.

    Now, here's what I find today in the Times by writer Ron Nixon:

    Mr. Gates says his concerns [about genealogical testing] date back to 2000, when a company told him his maternal ancestry could most likely be traced back to Egypt, probably to the Nubian ethnic group. Five years later, however, a test by a second company startled him. It concluded that his maternal ancestors were not Nubian or even African, but most likely European.

    Why the completely different results? Mr. Gates said the first company never told him he had multiple genetic matches, most of them in Europe. "They told me what they thought I wanted to hear," Mr. Gates said.

    It's entirely predictable from the samples and methods these companies are using. It's also a case where there are a lot of vested interests in being able to give people the results they want to hear. Nixon quotes Troy Duster:

    "My concern is that the marketing is coming before the science," said Troy Duster, a professor of sociology at New York University who was an adviser on the Human Genome Project and an author of the Science editorial.

    "People are making life-changing decisions based on these tests and may not be aware of the limitations," he added. "While I don't think any of the companies are deliberately misleading customers, they may have a financial incentive to tell people what they want to hear."

    Don't make life-changing decisions based on these tests! They can't tell you what tribe your ancestors came from. Period. Mitochondrial lineages have widespread distributions across Africa, and are not -- in most cases -- limited to any small region. That's the science.

    In the meantime, I have been hearing from a number of readers who have paid for the Genographic Project and are dissatisfied. I'm collecting these stories, as well as stories from people who are happy with the results. Feel free to send me an e-mail if you're in either group.

  • They clone horses, don't they?

    Fri, 2007-10-26 17:27 -- John Hawks

    "Horse racing editor" Mike Brunker checks in with an excellent MSNBC article on cloning in the horse racing world. Racing officials are, so far, against it, but cloning solves a number of problems for owners and breeders.

    Not least, what do you do when a gelding becomes a champion?

    Among the cloned horses is Clayton, the 14-month-old son of the legendary quarter horse Scamper, a gelding. Scamper won a record 10 consecutive barrel racing world championships from 1984 to 1993 in events sponsored by the Professional Rodeo Cowboys Association, and is the only barrel-racing horse to be inducted into the Pro Rodeo Hall of Fame. He also helped make his rider, Charmayne James, the first million-dollar cowgirl and the all-time leading money winner in barrel racing.

    ...

    [Co-owner Tony] Garritano said he and James paid $150,000 to ViaGen, an Austin, Texas, firm that is a leader in the commercial applications of cloning, to restore the otherwise extinct bloodlines of Scamper. Scamper, while still in good health at 30, can't be bred because he was gelded at an early age.

    I suppose that's a sinking feeling -- you've got a 10-time world champion quarter horse, and you can't breed him. And of course, castration may not be merely incidental -- it may have affected the performance -- so you can't just say never geld the horse. Particularly with utility horses, you may never have the idea you are going to breed one, but then he turns out to be a champion.

    "Carrying on bloodlines" seems to be one of the main appeals of cloning. The article describes how owners stop racing their champion thoroughbreds at 3 years old, just to put them out to stud, because that's where the money is. Perversely, they are breeding for a particular kind of early performance, which has effects on training and life histories of the animals.

    Critics have silly arguments. For example, "How much fun would it be to watch a basketball game with 10 Michael Jordans?" Well, if you didn't want to at least maintain the fiction that every team is nearly equally competitive, you wouldn't have an NBA draft! For horses, since the point of racing is to get to the finish line fastest, you're not really promoting phenotypic diversity now, are you?

    What I didn't know is that there are cloned mules in competition:

    An estimated 1,000 people turned out on June 5, 2006, to watch two cloned mules compete in the Humboldt Futurity in Winnemucca, Nev., a contest that was billed as the first race between cloned animals. One of the clones -- Idaho Gem -- finished third while his identical twin, Idaho Star, finished seventh in the field of eight. 

    Heck, I didn't even know there was mule racing!

    [T]he third mule, Utah Pioneer, never kicked it in.

    "He went into race training, but the feeling was that he just wasn't going to cut it as a racing mule," Vanderwall said. "He has returned to the university campus and is just hanging out."

    Uhhh...ummm... Oh, never mind.

    Meanwhile, the thoroughbreeders are dead-set against (it seems they profit too much on the current system, where your horse has 2 years to make good, and if not, you come back for more sperm), and the quarter-horse breeders are trying to find ways around the current ban (they run their horses for many years, have more of a feeder system in the utility horse market, and have non-regulated events of various kinds where they might run a cloned horse).

    What interesting politics!

  • Cold Spring Harbor denounces Watson

    Fri, 2007-10-19 10:55 -- John Hawks

    James Watson has now recanted his remarks, but not before his lab issued this terse press release:

    "The comments attributed to Dr. James Watson that first appeared in the October 14, 2007 edition of The Sunday Times U.K. are his own personal statements and in no way reflect the mission, goals, or principles of Cold Spring Harbor Laboratory's Board, administration or faculty. Dr. Watson is not the President of Cold Spring Harbor Laboratory and was not speaking on behalf of the institution.

    "The Board of Trustees, administration and faculty vehemently disagree with these statements and are bewildered and saddened if he indeed made such comments. Cold Spring Harbor Laboratory does not engage in any research that could even form the basis of the statements attributed to Dr. Watson."

    But Watson lives there!

    Ooooh...wait a minute! What about the Watson School of Biological Sciences? Watson is the chancellor! They do list 15 faculty members doing research in neuroscience, and 9 interested in learning and memory.

    I guess somebody over there must have had an "Oh, crap" moment...

    I think it's a pity they decided to issue this CYA statement instead of something genuinely meaningful. Why don't they devote one of their prestigious meetings to the topic of intelligence and race? Not a mere show trial, but a real encounter leading to (one or more) real accessible publications. We need less grandstanding, fewer sound bites, and more promotion of scientific reasoning.

    In the early days, their symposia included anthropologists as well as geneticists, but when I went to one around 10 years ago, it was clear that the old days had changed. Now you can see from the 2008 scheduled meetings there is not a single human-focused topic. They need desperately to revive their connection to evolutionary biology and human evolution in particular. Topics that actually concern society seem like a good start.

    (via SciAm)

    UPDATE (2007/10/19): Now Watson has been suspended from CSHL.

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  • Disagreeing with Hillary Clinton on human genetic differences

    Fri, 2007-06-15 17:19 -- John Hawks

    It's not really a politician's job to explain human biology to high school students. Still, with the number of politicians in New Hampshire this year, they seem to have been impressed into service. So Hillary Clinton was talking about biology to a graduating class in Manchester:

    When offering serious advice to the graduates, Clinton told them that their strengths lie in their differences -- those tiny differences that aren't at all significant.

    Clinton cited genetic research that shows humans are 99.9 percent the same and the graduates should embrace what they share, not the material they don't.

    "That the differences in how we look -- in our skin color, our eye color, our height -- stem from just one-tenth of 1 percent of our genes. And the differences among us -- our cultures, our religious beliefs, the music we like -- it is all so small a distinction in our sea of common humanity," she said.

    Now, pointing out that humans are very similar to each other is a worthwhile message. It emphasizes that we should work together to solve global problems, and that we shouldn't be distracted by minor differences. That is the bottom line in Clinton's speech, according to the AP story:

    "I know it seems daunting. We tend to focus a lot on the things that divide us -- the things we disagree about -- don't we?" she said. "But in doing so, we fail to take into account a basic scientific truth about who we are."

    I'm uncomfortable with this formulation, though.

    It's not just the "one-tenth of 1 percent of our genes" thing (although we differ by one-tenth of 1 percent of nucleotides, this is enough to make coding differences in a large fraction of our genes). Nor is it the new observations on copy number variation, which makes humans quite a bit more different from each other than the older figure.

    I disagree with Clinton: the average amount of genetic similarity between people is irrelevant to how we should act toward other people.

    Why irrelevant? Well, take the copy number variation as an example. It shows that humans are substantially more genetically different, in terms of nucleotides, than 0.1 percent. Does that mean it's OK to be a racist now? Does copy number variation provide another reason to diverge on global warming strategies?

    No, of course not. It's just irrelevant to these questions. Genetic similarities, whatever they may amount to, are not a reason for moral action.

    Am I just splitting hairs? Isn't it ultimately benign to point out how similar people are to each other? I mean, their usual reaction is "Gee whiz, 99.9 percent seems pretty alike to me!"

    But I actually think that moral arguments based on genetic "realities" are ultimately dangerous.

    For one thing, one-tenth of 1 percent of 3 billion is a heck of a large number -- 3 million nucleotide differences between two random genomes. Most of those genetic differences don't make a significant phenotypic difference. But a few do. There is no argument from the overall level of similarity (99.9 percent similar, or whatever) that cannot apply equally to some specific similarity or difference. Maybe some scientist says the average level of similarity is important. But some racist can just as easily say that the specific genes related to skin color are the important ones. The question of what is important is simply not a scientific one. The more we make these statistics out to be reasons for moral equality, the more we legitimize people who want to use genetics to prove moral inequality.

    For another thing, if we condition people to believe that we should treat people according to their genotype (which is, after all, mostly identical), then what happens tomorrow when scientists find some really important genetic difference? When it suddenly matters what allele you have?

    For instance, if a new disease emerged to which all people with type A blood happened to be immune?

    Clearly, the moral outcome is not to shrug and say the difference can't possibly exist because we are all 99.9 percent the same. Nor is the moral outcome for people with type-A blood to withhold tax money spent on research. The proper moral response is to find a cure for the disease, regardless of who it afflicts. Genetic information may be important toward finding that cure, but it cannot tell us whether we should find a cure, or how much effort we should spend on it.

    My bottom line: no matter how genetically similar or different people are, genetics cannot justify moral action. Although we are now in a time when it is fashionable to use genetics as a kind of self-evident argument for human equality, not very many years ago fashionable opinion found self-evident racial superiority. And given the increasing prevalence of genetic testing of all kinds, the pendulum may well swing back the other way, giving rise to various flavors of "allelism". I think it is better to recognize that moral action doesn't derive from scientific observations.

    (via Eye on DNA -- which also points out the problem of more extensive copy number variation)

    UPDATE (6/15/2007): A reader writes:

    To the extent you're just saying "is" doesn't make "ought", I find nothing to disagree with in your post. Unfortunately, though, your moral reasoning, while a step above Hillary's, still leaves something to be desired.

    "Nor is the moral outcome for people with type-A blood to withhold tax money spent on research. The proper moral response is to find a cure for the disease, regardless of who it afflicts."

    I'd like to see you justify this claim. What if the disease afflicts a tiny minority, and type-A people have their own diseases to worry about? You'll still stand up, courageously, and declare how other people's money should be spent?

    Simple answer: I have blood type O. You're damned right I'm going to tell them how to spend their money!

    (Less) simple answer: If we are going to give up the idea that moral reasoning is not identical to scientific reasoning, then we probably will observe (and accept) that different people have different beliefs about moral propriety. I don't know if this reader holds a belief inconsistent with mine, but someone very well might. Maybe they think that no government should be able to compel taxes, for example. Nothing wrong with that.

    But there are any number of genetic disorders that (a) are completely determined by genotype, and (b) affect a small minority of people. Our normal approach to these has not been to say, "Sorry, guess you're out of luck." My example of a novel disease afflicting non-type-A people has a dire appearance, because it seems so random. But of course it's no more random than cystic fibrosis.

    Do we have a moral obligation to conduct, pay for, and assist in finding a cure for CF? Probably not. We certainly don't have a moral obligation to exhaust the treasury, impress labor, or abandon all other research to find such a cure. No one can be expected to do the impossible. But I argue that it is morally desirable to conduct such research as is practical. And people who conduct such research do so not only for pecuniary reasons but also for moral ones.

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  • Finding new kin

    Wed, 2007-03-14 12:01 -- John Hawks

    Writer Corey Kilgannon in the NY Times writes about a "DNA reunion:"

    Ms. Higginsen, who runs a school for gospel singers in the brownstone, had organized this special family reunion to welcome to Harlem a newfound cousin she recently discovered through DNA testing.

    And in walked the new cousin: a Missouri cattle rancher named Marion West, 76. It was Mr. West's first visit to New York City, and he stood out partly because of his rancher outfit: black cowboy hat, shiny boots, string tie and a jacket advertising a feed company. But he also stood out because he was a white man greeted by a roomful of black New Yorkers embracing him as a long-lost member of their family.

    This is really an interesting story. Higginson persuaded her paternal uncle to get the Y chromosome profile, which led to West; both are descended from the initial Jamestown founders.

    The article covers the occasional conflicts between race self-identification and ancestry, mentions the recent Al Sharpton-Strom Thurmond connection, and the rancher's intuitive understanding of outbreeding:

    He brought laughter to the room when he spoke of cattle breeding.

    "I've been breeding cattle all my life, and I'll tell you, cross-breeding is better," he said. "You mate the black angus with the other breeds, and you have better, healthier offspring."

    I can think of no better way to illustrate that this kind of genetic testing is going mainstream.

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  • A profile of "disparity research" and cancer

    Wed, 2007-02-07 13:00 -- John Hawks

    Science writer Jennifer Couzin has an important profile of cancer researcher Olufunmilayo Olopade. I say it's important because the profile really presents a nuanced view of the relationship of biology, race, and health outcomes:

    It's long been known that black women, although less likely to suffer from the disease than whites, are far more likely to die of it, a difference traditionally attributed to lack of access to health care. But Olopade and a number of other scientists are finding something else: In more than a dozen studies, they've documented that breast tumors in African-American women tend to be more aggressive, less responsive to treatment, and more likely to strike before menopause than breast tumors in whites and other ethnic groups. The differences persist even when statisticians adjust for every variable they can think of, from body weight to education to the cancer treatment given.

    Still, the "science of disparity," as Olopade likes to call it, remains on the periphery of oncology research. Oncologists worry that by focusing on it, they'll be perceived as dismissive of the very real gulf in access to care. And they're generally reluctant to seek physiological distinctions between races. "It's such a contentious issue, and it causes people so much stress to conclude there may be a difference" in biology, says Wendy Woodward, a radiation oncologist who treats breast cancer at M. D. Anderson Cancer Center in Houston, Texas. She recently reported that even when black women with breast cancer receive the same treatment as whites in clinical trials, their chance of developing incurable metastases is about 20% greater.

    As knowledge about the genetics behind cancers increases, cancer specialists are making finer and finer distinctions between tumor types. "Breast cancer" is not a unitary disease, but a compilation of many different developmental pathways that lead to a common symptom -- tumors in the breast -- but potentially very different outcomes under the same treatment regime.

    The side effect of a more specialized, personal genetics is the observation that ancestry matters. Yet, ancestry exerts effects through environmental pathways as well as genetic ones:

    After confirming that fewer than 10% of the women in a group of patients from Nigeria had inherited a BRCA mutation, Olopade found that a startling 77% of 378 samples from Nigeria and Senegal were ER-negative [that is, had cancers of an estrogen receptor-negative type]. This contrasts with 39% in African Americans and 23% in Caucasians. Although many of the African women were young, and younger breast cancer patients are more prone to have ER-negative tumors, the numbers were still off the charts. "This just blew us away," she says. Those results, which Olopade and her colleagues presented at a cancer meeting in 2005 and are readying for publication, led her to believe that aggressive breast cancers in blacks are driven by an interplay of genes and environment.

    There is a hint at the end that stress-related hormonal changes may also increase the risk of these cancers, through epigenetic mechanisms.

    The article calls this line of inquiry, "disparity research." It's a name based in a public health discourse -- the analysis of disparities in health between racial groups. I think the name is unfortunate, because it characterizes differences only in terms of their negative effects. To the extent that the health outcomes may have genetic causes, those genes have evolutionary histories. Negative health outcomes are not their purpose, and research should examine the population variability in an evolutionary context. Likewise, the epigenetic responses to individual environments themselves have an evolutionary history.

    To examine the question as only one of disparity is to minimize it -- as if the only value of genes and ancestry is to avoid disease. That seems to be a message that Olopade herself understands:

    Olopade the straight talker responds forcefully to such criticisms, arguing that the aggressive disease she so often sees is not due only to poverty and lack of access to care.... Visiting the hospital room of a 50-year-old African-American breast cancer sufferer, who initially declined treatment and whose triple-negative disease has spread through her chest, she touches the woman gently on the shoulder, inquires about her family, and asks her to please listen to her doctors. "It keeps me thinking--that woman, why is she in the position she's in?" she wonders later. "If I don't have the experience of seeing patients like that, who walk in, and I studied disparities," she says, "I would never get it."

    The realization is that "genetic basis" does not mean fate. Genes cannot provide a full explanation, and their effects are not unchangeable. The concept of "personalized medicine" is that individual genetic variations matter: that understanding the different pathways that lead to common diseases can also lead to better treatments for individuals. At the same time, understanding the way that genes and epigenetics influence individual outcomes will uncover many of the ways that shared outcomes arise among people with shared ancestry.

    (via Yann Klementidis)

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  • What to do about the Sentinelese?

    Tue, 2006-07-11 16:38 -- John Hawks

    From Science last week, this article by Pallava Bagla on the Indian government's quandaries dealing with the Andaman Islands.

    Since 1991, ANA has enforced a hands-off policy toward the Sentinelese. The only exception was a mission to check on how they fared in the 2004 tsunami. When an Indian Air Force helicopter flew over the island, it was greeted with a barrage of arrows and turned back. Then last January, two fishers entered the waters of North Sentinel Island, reportedly to poach crabs. They were allegedly slain and buried in the sand, says Samir Acharya, president of the Society for Andaman and Nicobar Ecology in Port Blair, the Andaman capital. Police exercised restraint by not pressing charges or venturing into Sentinelese territory to retrieve the bodies, Acharya says.

    But other tribes are reaching out. The Jarawa, once hostile like the Sentinelese, began to visit ethnic Indian communities in 1998, sometimes seeking medical assistance. Their benign forays pose a challenge for the government: Heightened contact may erode tribal culture, whereas a hands-off approach would be difficult to sustain and justify, particularly when medical aid is sought. The government has since established a health outpost bordering Jarawa settlements (Bagla 2006:34).

    The huge disease risk from contact is only one of many problems, but it is in many ways the most imminent -- every continental disease has the potential to be a "bird flu" epidemic for the Andamanese.

    The Great Andamanese, who are said to have been 10,000 strong at the end of the 18th century, are down to 20 individuals, and the Onge number only 98.

    References:

    Bagla P. 2006. Isolate or engage? Indigenous islanders pose challenge for India. Science 313:34. DOI link

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Neandertals

For years, I've worked on their bones. Now I'm working on their genes. Read more about the science studying these ancient people.

Denisova

From a finger bone of an ancient human came the record of a completely unexpected population. My lab is working on the science of the Denisova genome.

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The advent of agriculture caused natural selection to speed up greatly in humans. We're uncovering some of the ways that populations have rapidly changed during the last 10,000 years.

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