|Title||Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Parham, P, Moffett, A|
|Journal||Nat Rev Immunol|
|Date Published||2013 Jan 21|
|Keywords||brain, brain evolution, HLA, immune, mhc|
Natural killer (NK) cells have roles in immunity and reproduction that are controlled by variable receptors that recognize MHC class I molecules. The variable NK cell receptors found in humans are specific to simian primates, in which they have progressively co-evolved with MHC class I molecules. The emergence of the MHC-C gene in hominids drove the evolution of a system of NK cell receptors for MHC-C molecules that is most elaborate in chimpanzees. By contrast, the human system of MHC-C receptors seems to have been subject to different selection pressures that have acted in competition on the immunological and reproductive functions of MHC class I molecules. We suggest that this compromise facilitated the development of the bigger brains that enabled archaic and modern humans to migrate out of Africa and populate other continents.
|Alternate Journal||Nat. Rev. Immunol.|
Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution.
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