|Title||Older males beget more mutations.|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Date Published||2012 Oct 29|
|Keywords||mutation, mutation rate, paternal age|
Three papers characterizing human germline mutation rates bolster evidence for a relatively low rate of base substitution in modern humans and highlight a central role for paternal age in determining rates of mutation. These studies represent the advent of a transformation in our understanding of mutation rates and processes, which may ultimately have public health implications.
|Alternate Journal||Nat. Genet.|
Older males beget more mutations.
For years, I've worked on their bones. Now I'm working on their genes. Read more about the science studying these ancient people.
From a finger bone of an ancient human came the record of a completely unexpected population. My lab is working on the science of the Denisova genome.
The advent of agriculture caused natural selection to speed up greatly in humans. We're uncovering some of the ways that populations have rapidly changed during the last 10,000 years.