|Title||North African Populations Carry the Signature of Admixture with Neandertals|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Sánchez-Quinto, F, Botigué, LR, Civit, S, Arenas, C, Ávila-Arcos, MC, Bustamante, CD, Comas, D, Lalueza-Fox, C|
|Secondary Authors||Caramelli, D|
|Keywords||africa, introgression, Neandertal DNA, North Africa|
One of the main findings derived from the analysis of the Neandertal genome was the evidence for admixture between Neandertals and non-African modern humans. An alternative scenario is that the ancestral population of non-Africans was closer to Neandertals than to Africans because of ancient population substructure. Thus, the study of North African populations is crucial for testing both hypotheses. We analyzed a total of 780,000 SNPs in 125 individuals representing seven different North African locations and searched for their ancestral/derived state in comparison to different human populations and Neandertals. We found that North African populations have a significant excess of derived alleles shared with Neandertals, when compared to sub-Saharan Africans. This excess is similar to that found in non-African humans, a fact that can be interpreted as a sign of Neandertal admixture. Furthermore, the Neandertal's genetic signal is higher in populations with a local, pre-Neolithic North African ancestry. Therefore, the detected ancient admixture is not due to recent Near Eastern or European migrations. Sub-Saharan populations are the only ones not affected by the admixture event with Neandertals.
|Short Title||PLoS ONE|
North African Populations Carry the Signature of Admixture with Neandertals
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