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A High-Coverage Genome Sequence from an Archaic Denisovan Individual.

Sat, 2012-09-01 22:22 -- John Hawks
TitleA High-Coverage Genome Sequence from an Archaic Denisovan Individual.
Publication TypeJournal Article
Year of Publication2012
AuthorsMeyer, M, Kircher, M, Gansauge, M-T, Li, H, Racimo, F, Mallick, S, Schraiber, JG, Jay, F, Prüfer, K, de Filippo, C, Sudmant, PH, Alkan, C, Fu, Q, Do, R, Rohland, N, Tandon, A, Siebauer, M, Green, RE, Bryc, K, Briggs, AW, Stenzel, U, Dabney, J, Shendure, J, Kitzman, J, Hammer, MF, Shunkov, MV, Derevianko, AP, Patterson, N, Andrés, AM, Eichler, EE, Slatkin, M, Reich, D, Kelso, J, Pääbo, S
JournalScience
Volume338
Start Page222
Issue6104
Pagination222-226
Date Published2012 Aug 30
ISSN1095-9203
KeywordsAncient DNA, denisova, Neandertal DNA, paleogenomics
Abstract

We present a DNA library preparation method that has allowed us to reconstruct a high-coverage (30X) genome sequence of a Denisovan, an extinct relative of Neandertals. The quality of this genome allows a direct estimation of Denisovan heterozygosity, indicating that genetic diversity in these archaic hominins was extremely low. It also allows tentative dating of the specimen on the basis of "missing evolution" in its genome, detailed measurements of Denisovan and Neandertal admixture into present-day human populations, and the generation of a near-complete catalog of genetic changes that swept to high frequency in modern humans since their divergence from Denisovans.
DOI10.1126/science.1224344
Alternate JournalScience
Citation KeyMeyer:Denisova:2012
PubMed ID22936568

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