|Title||A fine-scale chimpanzee genetic map from population sequencing.|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Auton, A, Fledel-Alon, A, Pfeifer, S, Venn, O, Ségurel, L, Street, T, Leffler, EM, Bowden, R, Aneas, I, Broxholme, J, Humburg, P, Iqbal, Z, Lunter, G, Maller, J, Hernandez, RD, Melton, C, Venkat, A, Nobrega, MA, Bontrop, R, Myers, S, Donnelly, P, Przeworski, M, McVean, G|
|Journal||Science (New York, N.Y.)|
|Date Published||2012 Apr 13|
|Keywords||chimpanzees, genetics, genomics, population structure, recombination|
To study the evolution of recombination rates in apes, we developed methodology to construct a fine-scale genetic map from high-throughput sequence data from 10 Western chimpanzees, Pan troglodytes verus. Compared to the human genetic map, broad-scale recombination rates tend to be conserved, but with exceptions, particularly in regions of chromosomal rearrangements and around the site of ancestral fusion in human chromosome 2. At fine scales, chimpanzee recombination is dominated by hotspots, which show no overlap with those of humans even though rates are similarly elevated around CpG islands and decreased within genes. The hotspot-specifying protein PRDM9 shows extensive variation among Western chimpanzees, and there is little evidence that any sequence motifs are enriched in hotspots. The contrasting locations of hotspots provide a natural experiment, which demonstrates the impact of recombination on base composition.
A fine-scale chimpanzee genetic map from population sequencing.
For years, I've worked on their bones. Now I'm working on their genes. Read more about the science studying these ancient people.
From a finger bone of an ancient human came the record of a completely unexpected population. My lab is working on the science of the Denisova genome.
The advent of agriculture caused natural selection to speed up greatly in humans. We're uncovering some of the ways that populations have rapidly changed during the last 10,000 years.