|Title||A “Copernican” Reassessment of the Human Mitochondrial DNA Tree from its Root|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Behar, M, van Oven , M, Rosset, S, Metspalu, M, Loogväli, E-L, Silva, M, Kivisild, T, Torroni, A, Villems, R|
|Journal||The American Journal of Human Genetics|
|Pagination||675 - 684|
|Keywords||migration, mtDNA, Neandertal DNA|
Mutational events along the human mtDNA phylogeny are traditionally identified relative to the revised Cambridge Reference Sequence, a contemporary European sequence published in 1981. This historical choice is a continuous source of inconsistencies, misinterpretations, and errors in medical, forensic, and population genetic studies. Here, after having refined the human mtDNA phylogeny to an unprecedented level by adding information from 8,216 modern mitogenomes, we propose switching the reference to a Reconstructed Sapiens Reference Sequence, which was identified by considering all available mitogenomes from Homo neanderthalensis. This “Copernican” reassessment of the human mtDNA tree from its deepest root should resolve previous problems and will have a substantial practical and educational influence on the scientific and public perception of human evolution by clarifying the core principles of common ancestry for extant descendants.
|Short Title||The American Journal of Human Genetics|
A “Copernican” Reassessment of the Human Mitochondrial DNA Tree from its Root
For years, I've worked on their bones. Now I'm working on their genes. Read more about the science studying these ancient people.
From a finger bone of an ancient human came the record of a completely unexpected population. My lab is working on the science of the Denisova genome.
The advent of agriculture caused natural selection to speed up greatly in humans. We're uncovering some of the ways that populations have rapidly changed during the last 10,000 years.