| Title | Perspectives on human genetic variation from the HapMap Project. |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | McVean, G, Spencer, CCA, Chaix, R |
| Journal | PLoS genetics |
| Volume | 1 |
| Issue | 4 |
| Pagination | e54 |
| Date Published | 2005 Oct |
| ISSN | 1553-7404 |
| Keywords | hapmap, population structure, snps |
| Abstract | The completion of the International HapMap Project marks the start of a new phase in human genetics. The aim of the project was to provide a resource that facilitates the design of efficient genome-wide association studies, through characterising patterns of genetic variation and linkage disequilibrium in a sample of 270 individuals across four geographical populations. In total, over one million SNPs have been typed across these genomes, providing an unprecedented view of human genetic diversity. In this review we focus on what the HapMap Project has taught us about the structure of human genetic variation and the fundamental molecular and evolutionary processes that shape it. |
| DOI | 10.1371/journal.pgen.0010054 |
| Alternate Journal | PLoS Genet. |
| Citation Key | McVean:HapMap:2005 |
| PubMed ID | 16254603 |
Perspectives on human genetic variation from the HapMap Project.
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