Jerry Coyne points to the extreme changes made possible by artificial breeding of dogs within the last 150 years: "Dog breeding: the debasement of the American cocker spaniel". One can look at the situation as an ecological change: former working dogs are now selected for their appearance much more than for their ability to do their former jobs. WIth attendant side effects.
For years, I've worked on their bones. Now I'm working on their genes. Read more about the science studying these ancient people.
From a finger bone of an ancient human came the record of a completely unexpected population. My lab is working on the science of the Denisova genome.
The advent of agriculture caused natural selection to speed up greatly in humans. We're uncovering some of the ways that populations have rapidly changed during the last 10,000 years.