|Title||Denisova admixture and the first modern human dispersals into southeast Asia and oceania.|
|Publication Type||Journal Article|
|Year of Publication||2011|
|Authors||Reich, D, Patterson, N, Kircher, M, Delfin, F, Nandineni, MR, Pugach, I, Ko, AM-S, Ko, Y-C, Jinam, TA, Phipps, ME, Saitou, N, Wollstein, A, Kayser, M, Pääbo, S, Stoneking, M|
|Journal||American journal of human genetics|
|Date Published||2011 Oct 7|
|Keywords||admixture, Ancient DNA, denisova, introgression, Neandertal DNA|
It has recently been shown that ancestors of New Guineans and Bougainville Islanders have inherited a proportion of their ancestry from Denisovans, an archaic hominin group from Siberia. However, only a sparse sampling of populations from Southeast Asia and Oceania were analyzed. Here, we quantify Denisova admixture in 33 additional populations from Asia and Oceania. Aboriginal Australians, Near Oceanians, Polynesians, Fijians, east Indonesians, and Mamanwa (a "Negrito" group from the Philippines) have all inherited genetic material from Denisovans, but mainland East Asians, western Indonesians, Jehai (a Negrito group from Malaysia), and Onge (a Negrito group from the Andaman Islands) have not. These results indicate that Denisova gene flow occurred into the common ancestors of New Guineans, Australians, and Mamanwa but not into the ancestors of the Jehai and Onge and suggest that relatives of present-day East Asians were not in Southeast Asia when the Denisova gene flow occurred. Our finding that descendants of the earliest inhabitants of Southeast Asia do not all harbor Denisova admixture is inconsistent with a history in which the Denisova interbreeding occurred in mainland Asia and then spread over Southeast Asia, leading to all its earliest modern human inhabitants. Instead, the data can be most parsimoniously explained if the Denisova gene flow occurred in Southeast Asia itself. Thus, archaic Denisovans must have lived over an extraordinarily broad geographic and ecological range, from Siberia to tropical Asia.
|Alternate Journal||Am. J. Hum. Genet.|
Denisova admixture and the first modern human dispersals into southeast Asia and oceania.
For years, I've worked on their bones. Now I'm working on their genes. Read more about the science studying these ancient people.
From a finger bone of an ancient human came the record of a completely unexpected population. My lab is working on the science of the Denisova genome.
The advent of agriculture caused natural selection to speed up greatly in humans. We're uncovering some of the ways that populations have rapidly changed during the last 10,000 years.