|Title||Oxytocin receptor gene (OXTR) is related to psychological resources.|
|Publication Type||Journal Article|
|Year of Publication||2011|
|Authors||Saphire-Bernstein, S, Way, BM, Kim, HS, Sherman, DK, Taylor, SE|
|Journal||Proceedings of the National Academy of Sciences of the United States of America|
|Date Published||2011 Sep 13|
|Keywords||behavior, brain, hormones, neurotransmitters, oxytocin, psychology|
Psychological resources-optimism, mastery, and self-esteem-buffer the deleterious effects of stress and are predictors of neurophysiological and psychological health-related outcomes. These resources have been shown to be highly heritable, yet the genetic basis for this heritability remains unknown. Here, we report a link between the oxytocin receptor (OXTR) SNP rs53576 and psychological resources, such that carriers of the "A" allele have lower levels of optimism, mastery, and self-esteem, relative to G/G homozygotes. OXTR was also associated with depressive symptomatology. Mediation analysis indicates that the effects of OXTR on depressive symptoms may be largely mediated by the influence of OXTR on psychological resources.
|Alternate Journal||Proc. Natl. Acad. Sci. U.S.A.|
Oxytocin receptor gene (OXTR) is related to psychological resources.
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