|Title||Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes|
|Publication Type||Journal Article|
|Year of Publication||2006|
|Authors||Grant, SFA, Thorleifsson, G, Reynisdottir, I, Benediktsson, R, Manolescu, A, Sainz, J, Helgason, A, Stefansson, H, Emilsson, V, Helgadottir, A, Styrkarsdottir, U, Magnusson, KP, Walters, BG, Palsdottir, E, Jonsdottir, T, Gudmundsdottir, T, Gylfason, A, Saemundsdottir, J, Wilensky, RL, Reilly, MP, Rader, DJ, Bagger, Y, Christiansen, C, Gudnason, V, Sigurdsson, G, Thorsteinsdottir, U, Gulcher, JR, Kong, A, Stefansson, K|
|Keywords||ancestral, CDCV, diabetes, risk|
NM\_030756We have previously reported suggestive linkage of type 2 diabetes mellitus to chromosome 10q1. We genotyped 228 microsatellite markers in Icelandic individuals with type 2 diabetes and controls throughout a 10.5-Mb interval on 10q. A microsatellite, DG10S478, within intron 3 of the transcription factor 7–like 2 gene (TCF7L2; formerly TCF4) was associated with type 2 diabetes (P = 2.1 10-9). This was replicated in a Danish cohort (P = 4.8 10-3) and in a US cohort (P = 3.3 10-9). Compared with non-carriers, heterozygous and homozygous carriers of the at-risk alleles (38% and 7% of the population, respectively) have relative risks of 1.45 and 2.41. This corresponds to a population attributable risk of 21%. The TCF7L2 gene product is a high mobility group box–containing transcription factor previously implicated in blood glucose homeostasis. It is thought to act through regulation of proglucagon gene expression in enteroendocrine cells via the Wnt signaling pathway2.
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
For years, I've worked on their bones. Now I'm working on their genes. Read more about the science studying these ancient people.
From a finger bone of an ancient human came the record of a completely unexpected population. My lab is working on the science of the Denisova genome.
The advent of agriculture caused natural selection to speed up greatly in humans. We're uncovering some of the ways that populations have rapidly changed during the last 10,000 years.