|Title||Genetic insights into the origins of Tibeto-Burman populations in the Himalayas.|
|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Gayden, T, Mirabal, S, Cadenas, AMM, Lacau, H, Simms, TMM, Morlote, D, Chennakrishnaiah, S, Herrera, RJJ|
|Journal||Journal of human genetics|
|Keywords||asia, china, import-2010-07-12, Late Pleistocene, tibet|
The Himalayan mountain range has played a dual role in shaping the genetic landscape of the region by (1) delineating east-west migrations including the Silk Road and (2) restricting human dispersals, especially from the Indian subcontinent into the Tibetan plateau. In this study, 15 hypervariable autosomal STR loci were employed to evaluate the genetic relationships of three populations from Nepal (Kathmandu, Newar and Tamang) and a general collection from Tibet. These Himalayan groups were compared to geographically targeted worldwide populations as well as Tibeto-Burman (TB) speaking groups from Northeast India. Our results suggest a Northeast Asian origin for the Himalayan populations with subsequent gene flow from South Asia into the Kathmandu valley and the Newar population, corroborating a previous Y-chromosome study. In contrast, Tamang and Tibet exhibit limited genetic contributions from South Asia, possibly due to the orographic obstacle presented by the Himalayan massif. The TB groups from Northeast India are genetically distinct compared to their counterparts from the Himalayas probably resulting from prolonged isolation and/or founder effects.Journal of Human Genetics advance online publication, 13 March 2009; doi:10.1038/jhg.2009.14.
Genetic insights into the origins of Tibeto-Burman populations in the Himalayas.
For years, I've worked on their bones. Now I'm working on their genes. Read more about the science studying these ancient people.
From a finger bone of an ancient human came the record of a completely unexpected population. My lab is working on the science of the Denisova genome.
The advent of agriculture caused natural selection to speed up greatly in humans. We're uncovering some of the ways that populations have rapidly changed during the last 10,000 years.