|Title||Common disorders are quantitative traits|
|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Plomin, R, Haworth, CMA, Davis, OSP|
|Journal||Nature Reviews Genetics|
|Keywords||2010-08-12, CDCV, disease, genomics, gwas, health, heritability|
After drifting apart for 100 years, the two worlds of genetics — quantitative genetics and molecular genetics — are finally coming together in genome-wide association (GWA) research, which shows that the heritability of complex traits and common disorders is due to multiple genes of small effect size. We highlight a polygenic framework, supported by recent GWA research, in which qualitative disorders can be interpreted simply as being the extremes of quantitative dimensions. Research that focuses on quantitative traits — including the low and high ends of normal distributions — could have far-reaching implications for the diagnosis, treatment and prevention of the problematic extremes of these traits.
Common disorders are quantitative traits
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