| Title | Mendelian disorders and multifactorial traits: the big divide or one for all? |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Antonarakis, SE, Chakravarti, A, Cohen, JC, Hardy, J |
| Journal | Nature reviews. Genetics |
| Volume | 11 |
| Pagination | 380–384 |
| Date Published | may |
| ISSN | 1471-0064 |
| Keywords | 2010-09-18, disease, fitness effects, gwas, health, mutation |
| Abstract | For the past century, Mendelian and multifactorial traits have existed at opposite ends of the disease spectrum in humans. Furthermore, the recent emphasis on genome-wide association studies for uncovering variants that underlie common diseases has risked deepening the divide - or has it? Four experienced human geneticists express their views on the changing landscape of human disease studies and the impact of new technologies and study designs on the age-old aim of connecting a genomic variant with its phenotypic consequences. |
| URL | http://dx.doi.org/10.1038/nrg2793 |
| DOI | 10.1038/nrg2793 |
| Citation Key | Antonarakis:2010 |
Mendelian disorders and multifactorial traits: the big divide or one for all?
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