|Title||Predicting genetic predisposition in humans: the promise of whole-genome markers|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||de los Campos, G, Gianola, D, Allison, DB|
|Journal||Nature Reviews Genetics|
|Keywords||2010-11-22, gwas, personalizedġenomics, phenotypes|
Although genome-wide association studies have identified markers that are associated with various human traits and diseases, our ability to predict such phenotypes remains limited. A perhaps overlooked explanation lies in the limitations of the genetic models and statistical techniques commonly used in association studies. We propose that alternative approaches, which are largely borrowed from animal breeding, provide potential for advances. We review selected methods and discuss the challenges and opportunities ahead.
Predicting genetic predisposition in humans: the promise of whole-genome markers
For years, I've worked on their bones. Now I'm working on their genes. Read more about the science studying these ancient people.
From a finger bone of an ancient human came the record of a completely unexpected population. My lab is working on the science of the Denisova genome.
The advent of agriculture caused natural selection to speed up greatly in humans. We're uncovering some of the ways that populations have rapidly changed during the last 10,000 years.