|Title||Hunter-gatherer genomic diversity suggests a southern African origin for modern humans|
|Publication Type||Journal Article|
|Year of Publication||2011|
|Authors||Henn, BM, Gignoux, CR, Jobin, M, Granka, JM, Macpherson, JM, Kidd, JM, Rodr\'ıguez-Botigué, L, Ramachandran, S, Hon, L, Brisbin, A, Lin, AA, Underhill, PA, Comas, D, Kidd, KK, Norman, PJ, Parham, P, Bustamante, CD, Mountain, JL, Feldman, MW|
|Journal||Proceedings of the National Academy of Sciences|
|Keywords||2011-03-08, africa, effective population size, mho, modern, out of africa, population structure|
Africa is inferred to be the continent of origin for all modern human populations, but the details of human prehistory and evolution in Africa remain largely obscure owing to the complex histories of hundreds of distinct populations. We present data for more than 580,000 SNPs for several hunter-gatherer populations: the Hadza and Sandawe of Tanzania, and the ≠Khomani Bushmen of South Africa, including speakers of the nearly extinct N|u language. We find that African hunter-gatherer populations today remain highly differentiated, encompassing major components of variation that are not found in other African populations. Hunter-gatherer populations also tend to have the lowest levels of genome-wide linkage disequilibrium among 27 African populations. We analyzed geographic patterns of linkage disequilibrium and population differentiation, as measured by FST, in Africa. The observed patterns are consistent with an origin of modern humans in southern Africa rather than eastern Africa, as is generally assumed. Additionally, genetic variation in African hunter-gatherer populations has been significantly affected by interaction with farmers and herders over the past 5,000 y, through both severe population bottlenecks and sex-biased migration. However, African hunter-gatherer populations continue to maintain the highest levels of genetic diversity in the world.
Hunter-gatherer genomic diversity suggests a southern African origin for modern humans
For years, I've worked on their bones. Now I'm working on their genes. Read more about the science studying these ancient people.
From a finger bone of an ancient human came the record of a completely unexpected population. My lab is working on the science of the Denisova genome.
The advent of agriculture caused natural selection to speed up greatly in humans. We're uncovering some of the ways that populations have rapidly changed during the last 10,000 years.